The KCNE2 K+ channel regulatory subunit: Ubiquitous influence, complex pathobiology
نویسندگان
چکیده
منابع مشابه
Disruption of the potassium channel regulatory subunit KCNE2 causes iron-deficient anemia
Iron homeostasis is a dynamic process that is tightly controlled to balance iron uptake, storage, and export. Reduction of dietary iron from the ferric to the ferrous form is required for uptake by solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 (Slc11a2) into the enterocytes. Both processes are proton dependent and have led to the suggestion of the importanc...
متن کاملMolecular Cloning and Functional Expression of the Equine K+ Channel KV11.1 (Ether à Go-Go-Related/KCNH2 Gene) and the Regulatory Subunit KCNE2 from Equine Myocardium
The KCNH2 and KCNE2 genes encode the cardiac voltage-gated K+ channel KV11.1 and its auxiliary β subunit KCNE2. KV11.1 is critical for repolarization of the cardiac action potential. In humans, mutations or drug therapy affecting the KV11.1 channel are associated with prolongation of the QT intervals on the ECG and increased risk of ventricular tachyarrhythmia and sudden cardiac death--conditio...
متن کاملIdentification and functional characterization of a K+ channel alpha-subunit with regulatory properties specific to brain.
The physiological diversity of K+ channels mainly depends on the expression of several genes encoding different alpha-subunits. We have cloned a new K+ channel alpha-subunit (Kv2.3r) that is unable to form functional channels on its own but that has a major regulatory function. Kv2.3r can coassemble selectively with other alpha-subunits to form functional heteromultimeric K+ channels with kinet...
متن کاملCorrigendum to “Disruption of the potassium channel regulatory subunit KCNE2 causes iron-deficient anemia” [Experimental Hematology, Vol. 42, Issue 12, p1053–1058.e1]
Corrigendum to ‘‘Disruption of the potassium channel regulatory subunit KCNE2 causes iron-deficient anemia’’ [Experimental Hematology, Vol. 42, Issue 12, p1053–1058.e1] Grace Salsbury, Emma L. Cambridge, Zoe McIntyre, Mark J. Arends, Natasha A. Karp, Christopher Isherwood, Carl Shannon, Yvette Hooks, The Sanger Mouse Genetics Project, Ramiro Ramirez-Solis, David J. Adams, Jacqueline K. White, a...
متن کاملCMF70 is a subunit of the dynein regulatory complex.
Flagellar motility drives propulsion of several important pathogens and is essential for human development and physiology. Motility of the eukaryotic flagellum requires coordinate regulation of thousands of dynein motors arrayed along the axoneme, but the proteins underlying dynein regulation are largely unknown. The dynein regulatory complex, DRC, is recognized as a focal point of axonemal dyn...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Gene
سال: 2015
ISSN: 0378-1119
DOI: 10.1016/j.gene.2015.06.061